Figure 1. A–J, GR IR is abundant in intact animals (A–E; n = 6), blunted after adrenalectomy (F–J), and selectively recovered after Dex or Cort administration. K–M, P–R, Seven minutes after injection of vehicle (n = 6), Cort (n = 6), or Dex (n = 10) into the circulation of adrenalectomized animals, GR is not recovered in the cortex (K, P), hippocampus (L, Q), or amygdala (M, R). N, O, S, T, In contrast, intravenous injection of Cort or Dex partly recovers GR IR in the PVN (N, S) and the ARC GR IR is fully recovered shortly after administration of Cort and Dex (O, T). Asterisks indicate statistically significant differences from the intact group: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Hash symbols indicate significant differences from the adrenalectomized plus vehicle group: #p < 0.05; ##p < 0.01; ###p < 0.001; ####p < 0.0001. All data are presented as the mean ± SEM. Scale bar, 100 µm.