Article Information
- Received February 26, 2015
- Revision received June 19, 2015
- Accepted June 23, 2015
- Published online July 2, 2015.
Author Information
- Jana Schaich Borg1,*,
- Mai-Anh Vu2,3,*,
- Cristian Badea4,5,6,
- Alexandra Badea4,
- G. Allan Johnson4,5,6,7 and
- Kafui Dzirasa1,2,5,8
- 1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710
- 2Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
- 3Center for Cognitive Neuroscience, Duke University Medical Center, Durham, North Carolina 27710
- 4Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710
- 5Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27710
- 6Department of Medical Physics, Duke University Medical Center, Durham, North Carolina 27710
- 7Department of Physics, Duke University Medical Center, Durham, North Carolina 27710
- 8Center for Neuroengineering, Duke University Medical Center, Durham, North Carolina 27710
- Correspondence should be addressed to Kafui Dzirasa, 361 Bryan Research Building, 311 Research Drive, Durham, NC 27710. E-mail: kafui.dzirasa{at}duke.edu.
Author contributions
↵2 Author Contributions: J.S.B. designed research, performed surgeries and histology, analyzed data, and wrote the paper with input from M.-A.V., C.B., A.B., G.A.J., and K.D. M.-A.V. designed research, performed registration with input from J.S.B., and analyzed data. C.B. performed the CT scans and CT image preprocessing. A.B. advised registration approach. G.A.J. advised overall imaging strategy and registration approach. K.D. advised surgical and histology strategies, and oversaw all experiments.
↵* J.S.B. and M.-A.V. contributed equally to this work.
Disclosures
↵1 The authors declare no competing financial interests.
↵3 This work is supported by Duke University Exploratory Research Fund (C.B. and G.A.J.), NIA K01-AG041211 (A.B.), Duke Center for In Vivo Microscopy (National Institutes of Health–National Institute of Biomedical Imaging and Bioengineering P41 EB015897), IMHRO RSA (K.D.), Duke University SOM startup funds (K.D.), and National Science Foundation (NSF) DGF1106401 (M.-A.V.). This work also used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF grant ACI-1053575. We thank James Cook (Center for In Vivo Microscopy, Duke University) for his help with scanning and Rainbo Hultman and Stephen Mague (Duke University) for providing their anatomical expertise to evaluate the described registration method.
Funding
National Institute on Aging
K01-AG041211National Institute of Health
P41 EB015897National Science Foundation Graduate Fellowship
DGF1106401Duke University Exploratory Research Fund
IMHRO RSA
Duke University School of Medicine startup funds
Extreme Science and Engineering Discovery Environment (XSEDE)
ACI-1053575
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